What is ibuprofen? How does it work (mechanism of action)?
Ibuprofen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include aspirin, naproxen (Aleve), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. Pain, fever, and inflammation are promoted by the release in the body of chemicals called prostaglandins. Ibuprofen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower levels of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved ibuprofen in 1974.
What are the uses for ibuprofen?
What are the side effects of ibuprofen?
- ringing in the ears,
- abdominal pain,
- constipation, and
- black, tarry stools,
- weakness, and
- dizziness upon standing (orthostatic hypotension)
- fluid retention (edema),
- blood clots,
- heart attacks,
- hypertension (high blood pressure), and
- heart failure.
What is the dosage for ibuprofen?
- For minor aches, mild to moderate pain, menstrual cramps, and fever, the usual adult dose is 200 or 400 mg every 4 to 6 hours.
- Arthritis is treated with 300 to 800 mg 3 or 4 times daily.
- When under the care of a physician, the maximum dose of ibuprofen is 3.2 g daily. Otherwise, the maximum dose is 1.2 g daily.
- Individuals should not use ibuprofen for more than 10 days for the treatment of pain or more than 3 days for the treatment of a fever unless directed by a physician.
- Children 6 months to 12 years of age usually are given 5-10 mg/kg of ibuprofen every 6-8 hours for the treatment of fever and pain. The maximum dose is 40 mg/kg daily.
- Juvenile arthritis is treated with 20 to 40 mg/kg/day in 3-4 divided doses.
- Ibuprofen should be taken with meals to prevent stomach upset.
Which drugs or supplements interact with ibuprofen?
- Ibuprofen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
- Ibuprofen may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
- When ibuprofen is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
- Ibuprofen increases the negative effect of cyclosporine on kidney function.
- Individuals taking oral blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid ibuprofen because ibuprofen also thins the blood, and excessive blood thinning may lead to bleeding.
- If aspirin is taken with ibuprofen there may be an increased risk for developing an ulcer.
- Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking ibuprofen or other NSAIDs.
- Combining SSRIs or selective serotonin reuptake inhibitors (for example, fluoxetine [Prozac], citalopram [Celexa], paroxetine [Paxil, Paxil CR, Pexeva) with NSAIDs may increase the likelihood of upper gastrointestinal bleeding.
Is ibuprofen safe to take if I'm pregnant or breastfeeding?
What brand names are available for ibuprofen?
- Pediatric Advil
- Advil Migraine
- PediaCareChildren’s Pain Reliever/Fever Reducer
- PediaCare Infant’s Pain Reliever/Fever Reducer Fever
- Neoprofen (ibuprofen lysine)
- Many others
What else should I know about ibuprofen?
- Tablets: 100, 200, 400, 600, and 800 mg
- Chewable tablets: 50 and 100 mg; Suspension: 100 mg/5 ml and 40 mg/ml
- Intravenous solution: 10 mg/ml, 100 mg/ml
How ibuprofen should be stored
- Ibuprofen should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
OTC and prescription availability
- You need a prescription from your doctor or other healthcare professional to obtain 400 to 800 mg strengths and injection.
- Lower doses of ibuprofen are available over-the-counter (OTC, without a prescription).